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Summary | Full Text | PDF (406 kb) - Cytoplasmic microtubules in polymorphonuclear leukocytes: Ef...Cytoplasmic microtubules in polymorphonuclear leukocytes: Effects of chemotactic stimulation and colchicine
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Summary | PDF (11437 kb) - Neutrophil granulocytes – Trojan horses for Leishmania major...Neutrophil granulocytes – Trojan horses for Leishmania major and other intracellular microbes?
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AbstractPolymorphonuclear neutrophil granulocytes (PMNs) possess numerous effector mechanisms to kill ingested pathogens as the first line of defence. However, several microorganisms evade intracellular killing in neutrophils, survive and retain infectivity. There is increasing evidence that several pathogens even multiply within neutrophils. Taking as a prototypic intracellular pathogen, we suggest an evasion strategy that includes the manipulation of PMNs in such a way that the pathogens are able to use the granulocytes as host cells. The ability to survive and maintain infectivity in PMNs subsequently enables these organisms to establish productive infection. These organisms can use granulocytes as Trojan horses before they enter their definitive host cells, the macrophages.
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Copyright © 1972 The Biophysical Society. All rights reserved.
Biophysical Journal, Volume 12, Issue 8, 1048-1055, 1 August 1972
doi:10.1016/S0006-3495(72)86142-3
Articles
A Two-Dimensional Random-Walk Analysis of Human Granulocyte Movement
Stephen C. Peterson and Peter B. Noble
Abstract
An equation describing a two-dimensional random walk with non-uniform step length is derived and applied to a cinephotomicrographic analysis of human granulocyte movement. The method is also applied to a generally recognized chemotactic movement.
