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- A Molecular Component of the Arterial Baroreceptor Mechanotr...A Molecular Component of the Arterial Baroreceptor Mechanotransducer
Neuron, Volume 21, Issue 6, 1 December 1998, Pages 1435-1441
Heather A Drummond, Margaret P Price, Michael J Welsh and Francois M Abboud
SummaryBaroreceptor nerve endings detect acute fluctuations in arterial pressure. We tested the hypothesis that members of the DEG/ENaC family of cation channels, which are responsible for touch sensation in , may be components of the baroreceptor mechanosensor. We found the γ subunit of ENaC localized to the site of mechanotransduction in baroreceptor nerve terminals innervating the aortic arch and carotid sinus. A functional role for DEG/ENaC members was suggested by blockade of baroreceptor nerve activity and baroreflex control of blood pressure by an amiloride analog that inhibits DEG/ENaC channels. These data suggest that ENaC subunits may be components of the baroreceptor mechanotransducer and pave the way to a better definition of mechanisms responsible for blood pressure regulation and hypertension.
Summary | Full Text | PDF (292 kb) - The TASK background K2P channels: chemo- and nutrient sensor...The TASK background K2P channels: chemo- and nutrient sensors
Trends in Neurosciences, Volume 30, Issue 11, 1 November 2007, Pages 573-580
Fabrice Duprat, Inger Lauritzen, Amanda Patel and Eric Honoré
AbstractSpecialized chemo- and nutrient-sensing cells share a common electrophysiological mechanism by transducing low O, high CO and low glucose stimuli into a compensatory cellular response: the closing of background K channels encoded by the K subunits. Inhibition of the TASK K channels by extracellular acidosis leads to an increased excitability of brainstem respiratory neurons. Moreover, hypoxic down-modulation of TASK channels is implicated in the activation of glomus cells in the carotid body. Stimulation of both types of cell leads to an enhanced ventilation and to cardiocirculatory adjustments. Differential modulation of TASK channels by acidosis and high glucose alters excitability of the hypothalamic orexin neurons, which influence arousal, food seeking and breathing. These recent results shed light on the role of TASK channels in sensing physiological stimuli.
Abstract | Full Text | PDF (1048 kb) - Oxygen-sensing by ion channels and the regulation of cellula...Oxygen-sensing by ion channels and the regulation of cellular functions
Trends in Neurosciences, Volume 19, Issue 10, 1 October 1996, Pages 435-440
José López-Barneo
AbstractFrom bacteria to mammals, ambient O tension influences such diverse cellular functions as gene expression, secretion, contraction and the patterns of electrical activity. Some of the effects of O are attributed to its interaction with various classes of voltage-dependent ion channels. In glomus cells of the carotid body, the differential properties of O-sensitive K and Ca channels help us to understand the basic features of O chemoreception. Modifications of ion-channel activity in response to changes in the partial pressure of O are also involved in the adjustments of vascular tone to hypoxia as well as in the response of chemoreceptors in pulmonary airways. Direct O-sensing by ion channels might also help to explain the alterations of brain function by low O tension. The O-sensitivity of ion-channel activity appears to be a broadly distributed phenomenon contributing to a wide variety of cellular responses to hypoxia. . (1996) 19, 435–440
Abstract | Full Text | PDF (1491 kb) - …more
Copyright © 1972 The Biophysical Society. All rights reserved.
Biophysical Journal, Volume 12, Issue 9, 1171-1182, 1 September 1972
doi:10.1016/S0006-3495(72)86153-8
Articles
Modeling the Carotid Sinus Baroreceptor
Ramachandra Srinivasan and Harvey B. Nudelman
Abstract
A mathematical model that describes the relationship between sinus pressure and nerve discharge frequency of the carotid sinus baroreceptor is presented. It is partly based upon the single-fiber data obtained by Clarke from the sinus nerve of a dog. The model takes into account what is currently known about the physiology of the baroreceptor. It consists of two nonlinear ordinary differential equations and eight free parameters. With one set of values for these eight parameters, the model reproduces well the experimental results reported by Clarke for positive ramp pressure inputs. Only three parameters needed to be adjusted in order to fit the dynamic data. The remaining five were obtained from static and steady-state data.
