| Hydrodynamic Recruitment of Rolling Leukocytes In Vitro Biophysical Journal, Volume 84, Issue 6, 1 June 2003, Pages 4182 Michael R. King and Daniel A. Hammer Full Text | PDF (48 kb) |
| Response to the Letter by King and Hammer Biophysical Journal, Volume 84, Issue 6, 1 June 2003, Pages 4183 Yi Zhang and Sriram Neelamegham Full Text | PDF (46 kb) |
| Electrostatic and hydrodynamic orientational steering effects in enzyme-substrate association Biophysical Journal, Volume 69, Issue 1, 1 July 1995, Pages 57-65 J. Antosiewicz and J.A. McCammon Abstract Diffusional encounters between a dumbbell model of a cleft enzyme and a dumbbell model of an elongated ligand are simulated by Brownian dynamics. The simulations take into account electrostatic and hydrodynamic interactions between the molecules. It is shown that the primary effect of inclusion of hydrodynamic interactions into the simulation is an overall decrease in the rate constant. Hydrodynamic orientational effects are of modest size for the systems considered here. They are manifested when changes in the rate constants for diffusional encounters favored by hydrodynamic interactions are compared with those favored by electrostatic interactions as functions of the overall strength of electrostatic interactions. The electrostatic interactions modify the hydrodynamic torques by modifying the drift velocity of the substrate toward the enzyme. We conclude that simulations referring only to electrostatic interactions between an enzyme and its ligand may yield rate constants that are somewhat (e.g., 20%) too high, but provide realistic descriptions of the orientational steering effects in the enzyme-ligand encounters. Abstract | PDF (1241 kb) |
Copyright © 1983 The Biophysical Society. All rights reserved.
Biophysical Journal, Volume 44, Issue 2, 185-190, 1 November 1983
doi:10.1016/S0006-3495(83)84290-8
Research Article
R.D. Jones, C.L. Lemanski and T.J. Jones
Using a low Reynold's number hydrodynamic model, the adhesive force in Giardia is calculated. It is shown that this force is larger than typical forces that would tend to detach the organism.