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AbstractDisturbances of breathing arising from failures of the respiratory center are not uncommon. Among them, breath holding and apnea occur most frequently as consequences of pulmonary and cardiac diseases, hypoxia, head trauma, cerebral inflammatory processes, genetic defects, degenerative brain diseases, alcoholism, deep anesthesia and drug overdose. They are often life-threatening and fail to respond to existing pharmacotherapies. After extensive research, there is now a reliable basis for new strategies to treat respiratory disturbances by pharmacological manipulation of intracellular signaling pathways, particularly those involving the serotonin receptor family. Specific activation of these pathways effectively prevails respiratory disturbances and can be extended to treatment of life-threatening respiratory disorders in patients.
Abstract | Full Text | PDF (1299 kb) - Lipodystrophy associated with highly active anti-retroviral ...Lipodystrophy associated with highly active anti-retroviral therapy for HIV infection: the adipocyte as a target of anti-retroviral-induced mitochondrial toxicity
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Copyright © 1965 The Biophysical Society. All rights reserved.
Biophysical Journal, Volume 5, Issue 1, 27-46, 1 January 1965
doi:10.1016/S0006-3495(65)86701-7
Articles
A Mathematical Model of the Human Respiratory Control System
Howard T. Milhorn, Richard Benton, Richard Ross and Arthur C. Guyton
Abstract
The respiratory system exhibits the properties of a control system of the regulator type. Equations describing this biological control system have been derived. Transient and steady-state solutions for various CO2 and O2 step input disturbances were obtained utilizing a digital computer and are compared with experimental results. The effectiveness of the respiratory system as a regulator is investigated. Further extensions of the model are suggested.
