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Biophys. J. BioFAST: First Published December 1, 2004. doi:10.1529/biophysj.104.055723
© 2004 by the Biophysical Society.

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BIOPHYSICAL LETTERS

Properties of Metabolic Networks: Structure vs. Function

Radhakrishnan Mahadevan 1* and Bernhard Palsson 2

1 Genomatica Inc.
2 University of California, San Diego

* To whom correspondence should be addressed. E-mail: rmahadevan{at}genomatica.com.

Submitted on November 4, 2004
Revised on November 16, 2004
Accepted on 18 November 2004


  Abstract
Biological data from high-throughput technologies describing the network components (genes, proteins, metabolites) and their associated interactions have driven the reconstruction and study of structural (topological) properties of large-scale biological networks. In this article, we address the relation of the functional and structural properties by using extensively experimentally validated genome-scale metabolic network models to compute observable functional states of a micro-organism and compare the 'structure vs. function' attributes of metabolic networks. It is observed that, functionally speaking, the essentiality of reactions in a node are not correlated with node connectivity as structural analyses of other biological networks have suggested. These findings are illustrated with the analysis of the genome-scale biochemical networks of three species with distinct modes of metabolism. These results also suggests fundamental differences among different biological networks arising out of their representation and functional constraints.

Key Words: Constraint-based Models, Error, Attack Tolerance, Essentiality, Genome-scale Metabolic Networks, Network Biology, Network Characterization




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Copyright © 2004 by the Biophysical Society.