Cover picture: Multiscale three-dimensional simulations of the epithelial to mesenchymal transition: Plots showing how malfunctions related with the intracellular regulation of soluble β-catenin can alter the epithelial configuration of a layer of cells producing the epithelial-mesenchymal transition.When the concentration of soluble β-catenin is overregulated, β-catenin is transported into the nucleus to interact with transcription factors. As a result, the cell detaches from its neighbors and becomes motile (yellow). Cell-cell detachment induces an upregulation of soluble β-catenin in the local neighbors, leading to the epithelial-mesenchymal transition. See the article by Ramis-Conde et al. on page 155.