Cover picture: Gating pathways of Escherichia coli-MscL during patch-clamp experiment. The first three columns show the simulated pathways from closed (t = 0) to half open (t = 0.5) to fully open (t = 1.0) using the molecular dynamicsdecorated finite element method. The opened configuration agrees with the structural model (rightmost column) proposed by Sukharev and Anishkin (6). See the article by Tang et al. on page 581.